SCD status

Aptamer therapy for SCD?

In this issue of Blood, Gutsaeva et al describe an aptamer with high affinity for murine P-selectin and its efficacy in preventing vaso-occlusion in a mouse sickle cell disease (SCD) model.1 Each year, more than 200 000 children are born with SCD,2 yet there is a paucity of treatment options available for sufferers.3 The disease is caused by homozygous expression of a mutation in the beta globi...

Scd Patterns Have Singular Diffraction

Among the many families of nonperiodic tilings known so far, SCD tilings are still a bit mysterious. Here, we determine the diffraction spectra of point sets derived from SCD tilings and show that they have no absolutely continuous part, that they have a uniformly discrete pure point part on the axis Re3, and that they are otherwise supported on a set of concentric cylinder surfaces around this...

Erythroid DAMPs drive inflammation in SCD.

Dli after Allogeneic Bmt for Scd

Volume 40, September 2000 TRANSFUSION 1071 Sickle cell disease (SCD) may be associated with considerable morbidity and mortality, particularly as patients reach adulthood.1 Among the various therapeutic options, allogeneic HPC transplantation is the only treatment with proven curative potential.1,2 However, the underlying disease recurs in about 10 percent of patients.2 Donor lymphocyte infusio...

Hydrogen Vacancy Diffusion Parameters in ScH2_x and ScD

The temperature dependence of the nuclear spin-lattice relaxation rate R\ of Sc has been measured in scandium dihydrides and dideuterides. These data are satisfactorily accounted for by two contributions to /?,, R]e due to conduction electrons, and R]Q due to quadrupo le interaction fluctuations resulting f rom vacancy diffusion on the hydrogen (deuter ium) sublattice. Describing these fluctuat...